August 12, 2003CirculationOpen Access

Adenosine Diphosphate–Induced Platelet Aggregation Is Associated With P2Y ₁₂ Gene Sequence Variations in Healthy Subjects

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Why the study?

Is ADP-induced platelet aggregation associated with P2Y12 gene sequence variations in healthy subjects?

Population

Healthy subjects

Design

Cross-sectional

Authors

PFPierre FontanaVascular Medicine ADAnnabelle DupontInserm SGSophie GandrilleDélégation Paris 5

Discussion

Member takes

Implication

Hypothesis-generating for P2Y12 genetic effects on platelet reactivity; requires validation before informing antiplatelet strategies.

Structured PICO

Is ADP-induced platelet aggregation associated with P2Y12 gene sequence variations in healthy subjects?

Population

Healthy subjects

Intervention

P2Y12 receptor gene sequence variations (H2 haplotype)

Outcome

ADP-induced platelet aggregationsurrogate

The H2 haplotype of the P2Y12 receptor gene is associated with altered ADP-induced platelet aggregation, suggesting a potential genetic basis for variability in atherothrombosis risk and response to antiplatelet drugs.

Cite This Study

Fontana et al. (2003) studied this question.

synapsesocial.com/papers/69da216d0d540cafc58386c5 https://doi.org/10.1161/01.cir.0000085073.69189.88

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Adenosine Diphosphate–Induced Platelet Aggregation Is Associated With P2Y ₁₂ Gene Sequence Variations in Healthy Subjects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenosine Diphosphate–Induced Platelet Aggregation Is Associated With P2Y ₁₂ Gene Sequence Variations in Healthy Subjects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider