Does familial predisposition to adverse pregnancy outcomes increase the risk of cardiovascular disease in sisters?
Sisters of women with adverse pregnancy outcomes face a moderately increased risk of cardiovascular disease, suggesting shared genetic or environmental influences.
Sisters of women with APOs face a moderately increased risk of CVD, suggesting a genetic and/or environmental influence on the association between APOs and CVDs. These findings underscore the need for evaluating the effectiveness of targeted preventive measures in women with APOs and their sisters.
Mantel et al. (2024) studied this question.