Why the study?
Is midlife adiposity associated with poor cognition and late-life dementia?
Is midlife adiposity associated with poor cognition and late-life dementia?
Management of midlife adiposity may play a role in preventing late-life dementia and cognitive decline.
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Supports midlife adiposity-dementia link in observational data; leaves open whether interventions alter risk.
We show that adiposity is related to poor cognition, with metabolic consequences of obesity and cerebrovascular disease as potential mediators. The outcomes have clinical implications, supporting a role for the management of adiposity in the prevention of late-life dementia and cognitive decline.
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Morys et al. (2021) studied this question.
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