June 17, 2017Arthritis Research & TherapyOpen Access

Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis

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Abstract

miR-155 is upregulated in SSc. These results suggest that the inflammasome promotes the expression of miR-155 and that miR-155 is a critical miRNA that drives fibrosis.

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Cite This Study

Artlett et al. (2017) studied this question.

synapsesocial.com/papers/69da25f694a959ed41a3c0dc https://doi.org/10.1186/s13075-017-1331-z

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Abstract

miR-155 is upregulated in SSc. These results suggest that the inflammasome promotes the expression of miR-155 and that miR-155 is a critical miRNA that drives fibrosis.