September 20, 2022PLoS ONE61 citationsOpen Access

Trend of hand, foot, and mouth disease from 2010 to 2021 and estimation of the reduction in enterovirus 71 infection after vaccine use in Zhejiang Province, China

HWHaocheng WuZhejiang Center for Disease Control and Prevention MXMing XueXinjiang Medical University CWChen WuShandong University

Structured PICO

Does EV71 vaccination reduce the incidence of EV71 infections and HFMD in Zhejiang Province, China?

Population

Individuals in Zhejiang Province, China, from 2010 to 2021

Intervention

EV71 vaccination

Comparator

Estimated expected incidence without vaccination

Outcome

Incidence of EV71 infections and hand, foot, and mouth disease (HFMD)

EV71 vaccination is highly effective in reducing the incidence of EV71 infections and should be administered between 5 months and 5 years of age.

Abstract

Since 2010, the incidence of EV71 infections has shown an obvious downward trend. All types of viruses showed significant periodicity on the 1-year scale. The periodicity of the biennial peak is mainly related to EV71 and Cox A16 before 2017 and other enteroviruses since 2018. The half-year peak cycle of HFMD was mainly caused by EV71 and Cox A6 infection. The expected incidence will be 2.76 times(include the cases of 2020) and 2.43 times(exclude the cases of 2020) higher than the actual value assuming that the measures of vaccination are not taken. EV71 vaccines are very effective and should be administered in the age window between 5 months and 5 years.

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