Why the study?
Does sertraline improve depression and emotional distress in stroke patients with minor depression and less severe major depression?
Does sertraline improve depression and emotional distress in stroke patients with minor depression and less severe major depression?
Sertraline improves emotional distress, emotionalism, and quality of life in poststroke patients with minor to moderate depression, despite no difference in conventional depression rating scales compared to placebo.
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Supports sertraline for emotional distress, emotionalism, and QoL in poststroke minor-moderate depression; extends RCT evidence beyond core rating scales.
Poststroke depression as measured by a conventional depression rating scale improved over time irrespective of treatment. Positive effects specific to sertraline were identified in emotional distress, emotionalism, and QoL. The study indicates that poststroke emotional reactions comprise depression and other domains susceptible to pharmacologic therapy.
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Murray et al. (2005) studied this question.
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