We report herein an unprecedented protocol for aminotrifluoromethylation of alkenes. With Cu(OTf)₂ as the catalyst, the reaction of alkenes, (bpy)Zn(CF₃)₂, and N-fluorobis(benzenesulfonyl)imide (NFSI) at room temperature provides the corresponding aminotrifluoromethylation products in satisfactory yields with high regioselectivity opposite to those driven by CF₃ radical addition. The method exhibits a broad substrate scope and wide functional group compatibility. A mechanism involving N-radical addition to alkenes followed by trifluoromethylation of alkyl radicals is proposed.
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Xiao et al. (2019) studied this question.