Specific clinical, imaging, and genetic risk factors significantly increase the risk of sustained ventricular arrhythmias in patients with dilated cardiomyopathy, which can guide appropriate selection for ICD implantation.
In patients with DCM, the annual event rate of sustained ventricular arrhythmias is approximately 4.5%. This risk is considerably higher in younger patients with hypertension, prior (non-)sustained ventricular arrhythmia, decreased left ventricular ejection fraction, left ventricular dilatation, late gadolinium enhancement, and genetic mutations (PLN, LMNA, and FLNC). These results may help determine appropriate candidates for implantable cardioverter-defibrillator implantation.
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Sammani et al. (2020) studied this question.
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