Proteomic profiling reveals altered arterial networks and mitochondrial protein loss in human atherosclerosis, highlighting plasma biomarkers for coronary disease.
The human arterial proteome can be viewed as a complex network whose architectural features vary considerably as a function of anatomic location and the presence or absence of atherosclerosis. The data suggest important reductions in mitochondrial protein abundance in early atherosclerosis and also identify a subset of plasma proteins that are highly predictive of angiographically defined coronary disease.
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Herrington et al. (2018) studied this question.
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