The reactivity of monoclonal antiviral antibodies with normal tissues is a common phenomenon, highlighting the potential for molecular mimicry.
May signal off-target binding by antiviral mAbs; leaves open human relevance and molecular mimicry.
More than 600 monoclonal antiviral antibodies made against 11 different viruses were screened against 14 different organs from normal uninfected mice. Of these antiviral antibodies, 21, or approximately 3.5%, reacted with specific cells in these organs. Several of these antibodies were of the multiple-organ-reactive type and recognized antigens in more than one organ. It was concluded that the reactivity of monoclonal antiviral antibodies with normal tissues is a common phenomenon.
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Srinivasappa et al. (1986) studied this question.
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