Obese insulin-resistant subjects exhibit altered adipose tissue gene expression, highlighting potential molecular mechanisms underlying insulin resistance.
Should not yet change clinical practice in insulin resistance; leaves open validation of novel genes as therapeutic targets.
The major finding of this study was lower expression of mitochondrial respiratory pathway and defective induction of lipid metabolism pathways by insulin in insulin-resistant subjects. Moreover, the study reveals several novel genes whose aberrant regulation is associated with the obese insulin-resistant phenotype.
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Soronen et al. (2012) studied this question.
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