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January 1, 2017RSC AdvancesOpen Access

Osteocytes regulate osteoblast differentiation and osteoclast activity through Interleukin-6 under mechanical loading

Zhichao Hao Yuanyuan Ma Jun Wu Xianxian Li Helin Chen Jiefei Shen Hang Wang

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Abstract

Osteocytes are the major mechanosensors that respond to mechanical strain and regulate bone formation and resorption.

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Cite This Study

Hao et al. (2017) studied this question.

synapsesocial.com/papers/69da72c6ae64bec32b835e9d https://doi.org/10.1039/c7ra09308j

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The amazing osteocyteOriginal Research · 2010 · 2,284 citations
2Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathwaysOriginal Research · 2010 · 205 citations
3Effects of interleukin-6 on cellular function in UMR-106–01 osteoblastlike cellsOriginal Research · 1991 · 46 citations
4Lack of autocrine effects of IL-6 on human bone marrow stromal osteoprogenitor cellsOriginal Research · 1997 · 15 citations
5Activation of the Janus Kinase/STAT (Signal Transducer and Activator of Transcription) Signal Transduction Pathway by Interleukin-6-Type Cytokines Promotes Osteoblast Differentiation*Original Research · 1997 · 209 citations

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