Aging and the human gut microbiotaâ€”from correlation to causality

S. Saraswati; Ramakrishnan Sitaraman

doi:10.3389/fmicb.2014.00764

January 12, 2015SHILAP Revista de lepidopterologíaOpen Access

Aging and the human gut microbiotaâ€”from correlation to causality

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Key Points

Examine the dynamic relationship between human gut microbiota and host aging, advocating for a transition from purely correlative observations to causal mechanistic evidence.
Conceptual review and opinion analysis of evolutionary and genomic microbiology literature.
Evaluation of observational paradigms and translational frameworks linking microbial shifts to longevity and age-related decline.
Highlights that the majority of documented associations between altered microbiome profiles and aging phenotypes remain strictly correlative.
Identifies the necessity of functional mechanistic studies and controlled interventions to determine whether microbial shifts cause or merely reflect physiological aging.

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Implication

Opinion perspective examines age-related changes in gut microbiota in humans, highlighting the transition from associative links to causal mechanisms.

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Saraswati et al. (2015) studied this question.

synapsesocial.com/papers/69da7a74a6045d71bfa3cca3 https://doi.org/10.3389/fmicb.2014.00764

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Aging and the human gut microbiotaâ€”from correlation to causality

Key Points

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Aging and the human gut microbiotaâ€”from correlation to causality

Key Points

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Implication

Discussion

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