Why the study?
SARS-CoV-2 circulation in humans results in variants with diverse mutations in the spike, affecting transmissibility, immune escape, and potential host range shifts.
Population
Common laboratory mice
Comparison
Three VOCs bearing the N501Y mutation vs initial and Delta variants
Authors
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Suggests possible rodent reservoirs for N501Y variants; hypothesis-generating and requires ecological validation before surveillance implications.
SARS-CoV-2 variants with the N501Y mutation can infect and transmit between common laboratory mice, raising the possibility of wild rodent secondary reservoirs.
Montagutelli et al. (2021) studied this question.
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