This review recommends restarting oral anticoagulation 7 to 14 days after a gastrointestinal bleed, highlighting apixaban as a potentially preferred DOAC.
May guide post-GIB anticoagulation resumption now; leaves open confirmation of timing and DOAC choice in prospective RCTs.
Anticoagulation therapy resumption is recommended, with resumption being considered between 7 and 14 days following GIB regardless of the therapy chosen. Data for warfarin management after GIB should be applied with caution to direct oral anticoagulants (DOACs) because of the quicker onset and experimental nature of reversal agents. Apixaban may be a preferred option when restarting a DOAC therapy.
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Kido et al. (2017) studied this question.
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