Why the study?
Do steroid-eluting endocardial pacemaker leads lower voltage stimulation thresholds and reduce peri-electrode fibrous tissue formation compared to nonsteroid leads in dogs?
Population
6 dogs
Comparison
Steroid-eluting endocardial pacemaker leads… vs Nonsteroid endocardial pacemaker leads implanted…
Design
Preclinical
Follow-up
6 weeks
Authors
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May warrant human trials of steroid-eluting leads; leaves open clinical translation from canine model.
Do steroid-eluting endocardial pacemaker leads lower voltage stimulation thresholds and reduce peri-electrode fibrous tissue formation compared to nonsteroid leads in dogs?
Steroid-eluting pacemaker leads reduce voltage stimulation thresholds and peri-electrode fibrous tissue formation in a canine model, likely due to anti-inflammatory effects.
Radovsky et al. (1988) studied this question.
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