Randomized double blind placebo-controlled trial ofSaccharomyces cerevisiaeCNCM I-3856 in irritable bowel syndrome: improvement in abdominal pain and bloating in those with predominant constipation

In this study, S. cerevisiae I-3856 at the dose of 1000 mg per day does not improve intestinal pain and discomfort in general IBS patients. However, it seems to have an effect in the subgroup with constipation which needs further studies to confirm (NCT01613456 in ClinicalTrials.gov registry).