Why the study?
Do variant alleles in the ABCB1 gene increase the risk of sudden cardiac death in digoxin users?
Do variant alleles in the ABCB1 gene increase the risk of sudden cardiac death in digoxin users?
The ABCB1 genotype may modify the risk of cardiac digoxin toxicity, increasing the risk of sudden cardiac death in digoxin users.
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ABCB1 variants may flag higher SCD risk on digoxin; hypothesis-generating and requires prospective validation before any clinical use.
In this study, we showed that in digoxin users variant alleles at each of the three loci in the ABCB1 gene were associated with an increased risk of SCD compared with digoxin users with none or one T allele. If replicated, the findings imply that the ABCB1 genotype modifies the risk of cardiac digoxin toxicity.
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Niemeijer et al. (2015) studied this question.
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