Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 27, 2020The Journals of Gerontology Series A

Systematic Review and Meta-Analysis on the Associations of Polypharmacy and Potentially Inappropriate Medication With Adverse Outcomes in Older Cancer Patients

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Are polypharmacy and potentially inappropriate medication associated with adverse outcomes and mortality in older cancer patients?

Population

Older cancer patients

Comparison

Polypharmacy and PIM use vs non-use

Design

Systematic review and meta-analysis

Authors

LCLi‐Ju ChenKTKira TraresDLDana Clarissa Laetsch

Discussion

Loading...

Member takes

Overview

May warrant medication review in older cancer patients; leaves open causal effects on outcomes.

Structured PICO

Are polypharmacy and potentially inappropriate medication associated with adverse outcomes and mortality in older cancer patients?

P
Population
Older cancer patients
I
Intervention
Polypharmacy and Potentially Inappropriate Medication (PIM) use
O
Outcome
Adverse outcomes and all-cause mortalityhard clinical

Polypharmacy and potentially inappropriate medication use are associated with adverse outcomes and mortality in older cancer patients, though current evidence is heavily limited by confounding.

Limitations

  • About three-quarters of the studies identified did not adjust for comorbidity
  • Prone to confounding by indication

Cite This Study

Chen et al. (2020) studied this question.

synapsesocial.com/papers/69da8deea6045d71bfa3d141https://doi.org/10.1093/gerona/glaa128
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>2000 · 20,940 citations
  2. 2Burden and impact of multifactorial geriatric syndromes in allogeneic hematopoietic cell transplantation for older adults2019 · 38 citations
  3. 3Analysis of Prognostic Factors of Comprehensive Geriatric Assessment and Development of a Clinical Scoring System in Elderly Asian Patients With Cancer2011 · 205 citations
  4. 4Trim and Fill: A Simple Funnel‐Plot–Based Method of Testing and Adjusting for Publication Bias in Meta‐Analysis2000 · 14,330 citations