Why the study?
Does prediabetes defined by first measured HbA1c predict higher cardiovascular risk compared with HbA1c in the diabetes range?
Does prediabetes defined by first measured HbA1c predict higher cardiovascular risk compared with HbA1c in the diabetes range?
Prediabetes defined by first measured HbA1c is associated with a higher risk of MACE and all-cause mortality than HbA1c in the diabetes range, emphasizing the need for aggressive risk factor modification in prediabetic patients.
Suggests peak MACE risk near but below diabetes threshold; hypothesis-generating and should not yet change management.
In the Danish population screened for diabetes with HbA1c, the highest risk of MACE and all-cause mortality was found in subjects with HbA1c just below the diagnostic threshold for diabetes. Our results highlight the need for increased focus on the treatment of cardiovascular risk factors for subjects with prediabetes.
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Yahyavi et al. (2021) studied this question.
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