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April 20, 2015Cancer Cell InternationalOpen Access

B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway

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Abstract

B7-H3 in the regulation of the metastatic capacity of HCC cells makes itself a promising therapeutic target for anti-metastasis therapy.

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Cite This Study

Kang et al. (2015) studied this question.

synapsesocial.com/papers/69da9ab200ab073a278387e8 https://doi.org/10.1186/s12935-015-0195-z

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1HepatogastroenterologyOriginal Research · 2012 · 1,997 citations
2JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cellsOriginal Research · 2014 · 307 citations
3Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysisOriginal Research · 2004 · 296 citations
4Tumor microenviroment and hepatocellular carcinoma metastasisOriginal Research · 2013 · 94 citations
5B7‐H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis‐associated genesOriginal Research · 2011 · 164 citations