Neurofeedback Training versus Treatment-as-Usual for Alcohol Dependence: Results of an Early-Phase Randomized Controlled Trial and Neuroimaging Correlates

Leena Subramanian; Léon Skottnik; W. Miles Cox; Michael Lührs; Rachel McNamara; Kerenza Hood; Gareth Watson; Joseph R. Whittaker; Angharad N. Williams; Raman Sakhuja; Niklas Ihssen; Rainer Goebel; Rebecca Playle; David E.J. Linden

doi:10.1159/000513448

January 1, 2021European Addiction ResearchOpen Access

Neurofeedback Training versus Treatment-as-Usual for Alcohol Dependence: Results of an Early-Phase Randomized Controlled Trial and Neuroimaging Correlates

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Why the study?

Does rtfMRI-neurofeedback improve outcomes compared to treatment-as-usual in currently abstinent patients with alcohol dependence?

Key Points

To evaluate the feasibility and neuroimaging correlates of real-time functional MRI neurofeedback targeting salience network cue reactivity compared to treatment-as-usual in alcohol dependence.
Early-phase randomized controlled trial comparing real-time functional MRI (rtfMRI) neurofeedback training against treatment-as-usual.
Intervention delivered to currently abstinent individuals with alcohol dependence, targeting salience network hyperactivity evoked by alcohol cues.
Real-time fMRI neurofeedback targeting alcohol cue-induced salience network hyperactivity was demonstrated to be feasible in currently abstinent patients with alcohol dependence.

Structured PICO

Does rtfMRI-neurofeedback improve outcomes compared to treatment-as-usual in currently abstinent patients with alcohol dependence?

P

Population

Currently abstinent patients with alcohol dependence

I

Intervention

rtfMRI-neurofeedback targeting hyperactivity of the salience network in response to alcohol cues

C

Comparator

Treatment-as-Usual

O

Outcome

Feasibility

rtfMRI-neurofeedback is a feasible intervention for currently abstinent patients with alcohol dependence.

Implication

Supports feasibility of rtfMRI-neurofeedback in alcohol dependence; leaves open efficacy versus treatment-as-usual.

Abstract

We demonstrated that rtfMRI-neurofeedback targeting hyperactivity of the salience network in response to alcohol cues is feasible in currently abstinent patients with alcohol dependence.

Discussion

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Cite This Study

Subramanian et al. (2021) studied this question.

synapsesocial.com/papers/69da9aed387cf7069868705f https://doi.org/10.1159/000513448

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Neurofeedback Training versus Treatment-as-Usual for Alcohol Dependence: Results of an Early-Phase Randomized Controlled Trial and Neuroimaging Correlates

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Neurofeedback Training versus Treatment-as-Usual for Alcohol Dependence: Results of an Early-Phase Randomized Controlled Trial and Neuroimaging Correlates

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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