Epigenomic analysis reveals altered DNA methylation of ER alpha targets in uterine leiomyomas, suggesting an epigenetic trigger for stem cell transformation and estrogen response.
Aberrant DNA methylation and its related transcriptional aberration were associated with cancer processes, which may represent a critical initial mechanism that triggers transformation of a single tumor stem cell that will eventually develop into a monoclonal leiomyoma tumor. The aberrant epigenetic regulation of ER alpha-target genes also may contribute to the aberrant response to estrogen, which is involved in the development of uterine leiomyomas after menarche.
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Maekawa et al. (2013) studied this question.
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