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September 10, 2007Clinical EndocrinologyOpen Access

The clinical response to somatostatin analogues in acromegaly correlates to the somatostatin receptor subtype 2a protein expression of the adenoma

Stine Lyngvi Fougner Olivera Casar‐Borota Jens Petter Berg John Hald Jon Ramm‐Pettersen Jens Bollerslev

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Abstract

The clinical effect of octreotide correlates with the proportion of cells positive for SSTR2a in immunohistochemical staining, rather than the adenoma SSTR2a protein level. There may be a down-regulation of SSTR2a during octreotide treatment.

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Fougner et al. (2007) studied this question.

synapsesocial.com/papers/69daa8f03bc1ef7225684760 https://doi.org/10.1111/j.1365-2265.2007.03065.x

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Primary Medical Therapy for Acromegaly: An Open, Prospective, Multicenter Study of the Effects of Subcutaneous and Intramuscular Slow-Release Octreotide on Growth Hormone, Insulin-Like Growth Factor-I, and Tumor SizeCohort Study · 2002 · 282 citations
2Primary Treatment of Acromegaly with Octreotide LAR: A Long-Term (Up to Nine Years) Prospective Study of Its Efficacy in the Control of Disease Activity and Tumor ShrinkageCohort Study · 2006 · 228 citations
3The Antitumoral Effects of Somatostatin Analog Therapy in AcromegalyReview · 2005 · 253 citations
4A Critical Analysis of Pituitary Tumor Shrinkage during Primary Medical Therapy in AcromegalySystematic Review · 2005 · 216 citations
5Mapping of somatostatin receptor types in GH or/and PRL producing pituitary adenomasCase-Control Study · 2006 · 64 citations

More related papers

Somatostatin (SRIF) Receptor Subtype 2 and 5 Gene Expression in Growth Hormone-secreting Pituitary Adenomas: The Relationship with Endogenous SRIF Activity and Response to Octreotide2004
Somatostatin receptor subtype 2 and 5 in human GH‐secreting pituitary adenomas: analysis of gene sequence and mRNA expression2001
Quantitative analysis of somatostatin receptor subtype (SSTR1–5) gene expression levels in somatotropinomas and non-functioning pituitary adenomas2007

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