This multicenter atlas provides the first region-specific normative values for physiological high-frequency oscillations, establishing that fast ripples are rare in normal tissue and thus a strong candidate for identifying epileptogenic zones.
This multicenter atlas is the first to provide region-specific normative values for physiological HFO rates and HFA in common stereotactic space; rates above these can now be considered pathological. Physiological ripples are frequent in eloquent cortex. In contrast, physiological fast ripples are very rare, making fast ripples a good candidate for defining the epileptogenic zone. Ann Neurol 2018;84:374-385.
Frauscher et al. (Fri,) studied this question.
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