Are intracranial pressure waveform morphological metrics (AmpICP and PSI) associated with mortality in patients with traumatic brain injury?
Intracranial pressure waveform metrics (AmpICP and PSI) reflect distinct aspects of cerebrospinal compliance and are associated with mortality in traumatic brain injury.
AmpICP and PSI capture distinct aspects of cerebrospinal compliance. PSI appears to reflect age-related stiffening of the cerebrovascular system, while AmpICP, influenced by mean ICP, indicates acute volume compensatory changes. Combined, they provide a more comprehensive assessment of cerebrospinal volume-pressure compensation. Both morphological metrics are associated with mortality after TBI. As cerebrospinal compliance declines with age, older TBI patients become more susceptible to uncontrolled rises in ICP, which can worsen their outcome.
Kasprowicz et al. (Mon,) studied this question.