August 16, 2011Open Access
Ver artículo completoDiabetes Mellitus Worsens Diastolic Left Ventricular Dysfunction in Aortic Stenosis Through Altered Myocardial Structure and Cardiomyocyte Stiffness
PICO estructurado
Does diabetes mellitus worsen diastolic left ventricular dysfunction in aortic stenosis?
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Población
Subjects with Aortic Stenosis and Diabetes Mellitus (AS-DM)
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Intervención
Diabetes Mellitus (exposure)
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Resultado
Diastolic LV dysfunction, myocardial fibrosis, intramyocardial vascular advanced glycation end product deposition, and cardiomyocyte F(passive)surrogate
Diabetes mellitus exacerbates diastolic dysfunction in aortic stenosis via increased myocardial fibrosis, advanced glycation end product deposition, and cardiomyocyte stiffness due to titin hypophosphorylation.
Resumen
Worse diastolic LV dysfunction in AS-DM predisposes to heart failure and results from more myocardial fibrosis, more intramyocardial vascular advanced glycation end product deposition, and higher cardiomyocyte F(passive), which was related to hypophosphorylation of the N2B titin isoform.