This basic science study elucidates the complex signaling pathways, including ROS and Rho-kinase, underlying thrombin-induced pulmonary vasoconstriction.
This study elucidated the Ca²(+)- and MLC20 phosphorylation-independent ROS-mediated noncanonical mechanism as well as Ca²(+)- and MLC20 phosphorylation-dependent canonical mechanism that are involved in the thrombin-induced PAR₁-mediated pulmonary vasoconstriction. Rho-kinase was suggested to play multiple roles in the development of thrombin-induced pulmonary vasoconstriction.
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Maki et al. (2010) studied this question.
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