Why the study?
Does captopril scavenge hydrogen peroxide and prevent oxidant-induced cell injury in vitro?
Population
In vitro models including xanthine oxidase and hypoxanthine system, human renal tubular epithelial cells…
Comparison
Captopril (0.1-2.5 mM) or cysteine vs Enalaprilat or sulfhydryl group blocked with…
Design
Preclinical
Follow-up
0-120 min (incubation time)
Authors
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Cautions against clinical extrapolation from this in vitro model; hypothesis-generating for thiol-dependent antioxidant effects in renal injury.
Does captopril scavenge hydrogen peroxide and prevent oxidant-induced cell injury in vitro?
Captopril, due to its sulfhydryl group, can scavenge hydrogen peroxide and slightly reduce oxidant-induced cell injury in vitro.
Sharon Andreoli (1993) studied this question.