Why the study?
Do plasma angiopoietin-2/-1 ratios correlate with organ injury and clinical outcomes in children with sepsis?
Do plasma angiopoietin-2/-1 ratios correlate with organ injury and clinical outcomes in children with sepsis?
Elevated plasma angiopoietin-2/-1 ratios in the acute phase of pediatric sepsis correlate with organ injury and worse clinical outcomes.
Hypothesis-generating for endothelial biomarkers in pediatric sepsis; should not yet change practice or guidelines.
In the acute phase of sepsis in children, plasma angiopoietin-2/-1 ratios rise significantly above control levels and correlate with measures of organ injury and worse clinical outcomes after 24 hours. Our findings suggest that angiopoietin dysregulation begins early in sepsis and, if sustained, may promote greater organ injury that can lead to worse clinical outcomes.
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Richter et al. (2020) studied this question.
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