Why the study?
Does long-term low-dose aspirin increase the risk of major bleeding in real-world settings?
Does long-term low-dose aspirin increase the risk of major bleeding in real-world settings?
Real-world observational data confirms that the major bleeding risk associated with long-term low-dose aspirin is similar to the risk reported in randomized clinical trials.
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Supports applying RCT bleeding risk estimates to real-world patients; confirms consistency between observational and randomized evidence on low-dose aspirin.
The risks of major bleeding with low-dose aspirin in real-world settings are of a similar magnitude to those reported in randomized trials. These data will help inform clinical judgements regarding the use of low-dose aspirin in prevention of cardiovascular events.
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Rodrı́guez et al. (2016) studied this question.
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