November 13, 2012Open Access

Inhibition of Cyclooxygenase-2 Reduces Hypothalamic Excitation in Rats with Adriamycin-Induced Heart Failure

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Abstract

These results suggest that PVN COX-2 may be an intermediary step for PVN neuronal activation and excitatory neurotransmitter release, which further contributes to sympathoexcitation and RAS activation in adriamycin-induced heart failure. Treatment with COX-2 inhibitor attenuates sympathoexcitation and RAS activation in adriamycin-induced heart failure.

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Zheng et al. (Tue,) studied this question.

synapsesocial.com/papers/69daba11387cf706986877b6 — DOI: https://doi.org/10.1371/journal.pone.0048771

Authors

Min Zheng

Centre National de la Recherche Scientifique

Yu‐Ming Kang

Xi'an Jiaotong University

Wei Liu

Fudan University

Journals

SHILAP Revista de lepidopterología

PLoS ONE

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Institutions

Xi'an Jiaotong University

Shantou University

Shantou University Medical College

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Building similarity graph...

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Inhibition of Cyclooxygenase-2 Reduces Hypothalamic Excitation in Rats with Adriamycin-Induced Heart Failure

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion