June 3, 2025Open Access

Monovalent mRNA XBB.1.5 vaccine effectiveness against COVID-19 hospitalization in Quebec, Canada: Impact of variant replacement and waning protection during 10-month follow-up

SCSara CarazoCentre hospitalier universitaire de Québec DSDanuta M. SkowronskiUniversity of British Columbia NBNicholas BrousseauInstitut National de Santé Publique du Québec

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Abstract

Among individuals aged 60 years or older, mRNA XBB-vaccination provided meaningful, albeit limited to first four months post-vaccination, protection against COVID-19 hospitalization due to XBB, JN and KP subvariants. Better vaccines are needed to effectively protect older adults against COVID-19 hospitalizations.

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