A clinical guide to hereditary cancer panel testing: evaluation of gene-specific cancer associations and sensitivity of genetic testing criteria in a cohort of 165,000 high-risk patients

Holly LaDuca; Eric C. Polley; Amal Yussuf; Lily Hoang; Stephanie Gutierrez; Steven N. Hart; Siddhartha Yadav; Chunling Hu; Jie Na; David E. Goldgar; Kelly Fulk; Laura P. Smith; Carolyn Horton; Jessica Profato; Tina Pesaran; Chia-Ling Gau; Melissa Pronold; Brigette Tippin Davis; Elizabeth Chao; Fergus J. Couch; Jill S. Dolinsky

doi:10.1038/s41436-019-0633-8

Abstract

Opportunities to improve upon identification of patients at risk for hereditary cancer predisposition include revising BRCA1/2 and Lynch syndrome testing criteria to include additional clinically actionable genes with overlapping phenotypes and relaxing testing criteria for associated cancers.

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LaDuca et al. (2019) studied this question.

synapsesocial.com/papers/69dabfaa37b5141e3ba3c8b5 https://doi.org/10.1038/s41436-019-0633-8

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A clinical guide to hereditary cancer panel testing: evaluation of gene-specific cancer associations and sensitivity of genetic testing criteria in a cohort of 165,000 high-risk patients

Abstract

Discussion

Cite This Study

A clinical guide to hereditary cancer panel testing: evaluation of gene-specific cancer associations and sensitivity of genetic testing criteria in a cohort of 165,000 high-risk patients

Abstract

Discussion

Cite This Study

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