This case report suggests a possible genetic etiology for apical ballooning syndrome by describing its occurrence in two sisters.
Does not alter management of apical ballooning syndrome; leaves open a possible genetic predisposition for further study.
Apical ballooning of the left ventricle was first introduced as takotsubo-like left ventricular dysfunction in 1990 by Satoh and colleagues. The syndrome is characterised by reversible extensive akinesia of the apical and mid-portions of the left ventricle with hypercontraction of the basal segment. For the first time two sisters with this syndrome are reported, suggesting a possible genetic aetiology.
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Pison et al. (2004) studied this question.
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