An ATP-fueled soft gel machine reconstructed from polymer-crosslinked actin muscle protein (“giant-actin”) and analogously modified myosin has been built by Osada and co-workers. The “giant-actin” gel filaments (several 1000 times larger by volume than native actin, see Figure) move along their myosin counterparts as fast as native F-actin. Such machines should work inside their body of origin without eliciting immunoreactions.
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Kakugo et al. (2002) studied this question.
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