April 24, 2025Open Access

Tailoring dual antiplatelet therapy for stroke prevention: a meta-analysis of timing, duration, regimen, and stroke subtypes

NANaif M. AlhawitiKing Saud bin Abdulaziz University for Health Sciences SFSherouk FoudaFuture University in Egypt NANaser D. AlotaibiKing Saud bin Abdulaziz University for Health Sciences

Structured PICO

Does dual antiplatelet therapy (DAPT) reduce recurrent ischemic stroke and MACE in patients at risk for recurrent stroke?

Population

Patients at risk for recurrent stroke

Intervention

Dual antiplatelet therapy (DAPT) using aspirin plus clopidogrel, initiated within 12-24 hours for a short-term duration (≤30 days)

Outcome

Recurrent ischemic stroke and MACEhard clinical

Short-term DAPT (≤30 days) with aspirin and clopidogrel initiated within 12-24 hours appears optimal for recurrent stroke prevention.

Abstract

DAPT effectively reduces recurrent ischemic stroke and MACE, especially when initiated within 12-24 h using aspirin plus clopidogrel. Short-term DAPT (≤30 days) may be optimal for recurrent stroke prevention. Clinicians should carefully weigh benefits and risks when personalizing DAPT strategies.

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