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March 1, 1998Journal of Clinical Oncology208 citations

Decision analysis of prophylactic mastectomy and oophorectomy in BRCA1-positive or BRCA2-positive patients.

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VGVictor R. GrannColumbia University Irving Medical CenterKPK. PanageasMemorial Sloan Kettering Cancer CenterWWWilliam WhangElectrophysiology

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Abstract

Among women who test positive for a BRCA1 or BRCA2 gene mutation, prophylactic surgery at a young age substantially improves survival, but unless genetic risk of cancer is high, provides no benefit for quality of life. Prophylactic surgery is cost-effective for years of life saved compared with other medical interventions that are deemed cost-effective.

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Cite This Study

Grann et al. (1998) studied this question.

synapsesocial.com/papers/69dad7ca4a1e15904c83675ehttps://doi.org/10.1200/jco.1998.16.3.979
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