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August 15, 2008JAIDS Journal of Acquired Immune Deficiency SyndromesOpen Access

Poor Initial CD4+ Recovery With Antiretroviral Therapy Prolongs Immune Depletion and Increases Risk for AIDS and Non-AIDS Diseases

Jason V. Baker Grace Peng Joshua Rapkin David Krason Cavan Reilly Winston Cavert Donald I. Abrams Rodger D. MacArthur Keith Henry James D. Neaton

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Abstract

Impaired immune recovery, despite effective ART, results in longer time spent at low CD4+, thereby increasing risk for a broad category of HIV-related morbidity and mortality conditions.

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Cite This Study

Baker et al. (2008) studied this question.

synapsesocial.com/papers/69dadaf67a67537a8ba3cac2 https://doi.org/10.1097/qai.0b013e31817bebb3

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or LessRCT · 1997 · 2,640 citations
2Positive Effects of Combined Antiretroviral Therapy on CD4 <sup>+</sup> T Cell Homeostasis and Function in Advanced HIV DiseaseOriginal Research · 1997 · 1,785 citations
3Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus InfectionOriginal Research · 1998 · 9,408 citations
4CD4+ Count–Guided Interruption of Antiretroviral TreatmentCohort Study · 2006 · 2,234 citations
5Effective therapy has altered the spectrum of cause-specific mortality following HIV seroconversionCohort Study · 2006 · 218 citations

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