Why the study?
What is the appropriate aortic diameter threshold for prophylactic surgery to prevent sudden death or aortic dissection in patients with Marfan syndrome?
What is the appropriate aortic diameter threshold for prophylactic surgery to prevent sudden death or aortic dissection in patients with Marfan syndrome?
An aortic diameter of 50 mm appears to be a safe and reasonable threshold for prophylactic aortic surgery in patients with Marfan syndrome.
May support 50 mm threshold in Marfan aortopathy; leaves open need for randomized confirmation.
Risk of sudden death or aortic dissection remains low in patients with Marfan syndrome and aortic diameter between 45 and 49 mm. Aortic diameter of 50 mm appears to be a reasonable threshold for prophylactic surgery.
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Jondeau et al. (2011) studied this question.
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