Fetuin-A links fatty liver to the pathophysiology of insulin resistance and atherosclerosis by inducing inflammation and repressing adiponectin.
We provide novel evidence that the secreted liver protein fetuin-A induces low-grade inflammation and represses adiponectin production in animals and in humans. These data suggest an important role of fatty liver in the pathophysiology of insulin resistance and atherosclerosis.
Hennige et al. (Wed,) studied this question.