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Fetuin-A links fatty liver to the pathophysiology of insulin resistance and atherosclerosis by inducing inflammation and repressing adiponectin.
We provide novel evidence that the secreted liver protein fetuin-A induces low-grade inflammation and represses adiponectin production in animals and in humans. These data suggest an important role of fatty liver in the pathophysiology of insulin resistance and atherosclerosis.
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Hennige et al. (2008) studied this question.
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