Why the study?
Does systemic thrombolytic therapy reduce mortality and PE recurrence in patients with acute PE?
Does systemic thrombolytic therapy reduce mortality and PE recurrence in patients with acute PE?
Reserve thrombolysis for hemodynamically unstable acute PE; confirms no mortality benefit in stable patients.
Thrombolytic therapy reduces total mortality, PE recurrence, and PE-related mortality in patients with acute PE. The decrease in overall mortality is, however, not significant in haemodynamically stable patients with acute PE. Thrombolytic therapy is associated with an increase of major and fatal or intracranial haemorrhage.
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Marti et al. (2014) studied this question.
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