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Registry analysis reveals distinct inflammatory biomarker clusters in severe asthma, suggesting discrete pathway activation patterns relevant for targeted biologic therapies.
There is significant overlap of biomarker positivity in severe asthma. Distinct clusters according to biomarker expression exhibit unique clinical characteristics, suggesting the occurrence of discrete patterns of underlying inflammatory pathway activation and providing pathogenic insights relevant to the era of monoclonal biologics.
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Denton et al. (2021) studied this question.
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