Various computational methods for determining protein producing regions in a given genome are based on engineering constructs such as hidden Markov models and neural networks. The work presents a coding theory approach to modeling the process of protein translation initiation. The messenger RNA (mRNA) is viewed as a noisy encoded message and the ribosome as a block code minimum distance decoder. The results of applying this model to the Escherichia coli K-12 are presented.
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May et al. (2003) studied this question.