Why the study?
Does CYP2C19*17 genotyping have clinical utility?
Does CYP2C19*17 genotyping have clinical utility?
CYP2C19*17 genotyping is unlikely to be clinically useful except for drugs with very narrow therapeutic indices.
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Genotyping CYP2C19*17 offers little clinical utility beyond narrow-index drugs; leaves open targeted validation in high-risk pharmacotherapy.
Assignment of CYP2C19*17 homozygotes as extensive metabolizers rather than ultrarapid metabolizers is adequate. CYP2C19*17 genotyping is unlikely to have clinical utility except for drugs with very narrow therapeutic indices.
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Li‐Wan‐Po et al. (2009) studied this question.
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