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February 13, 2018ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Open Access

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma

Natalie Cook Bristi Basu D. M. Smith Aarthi Gopinathan Jonathan J. Evans William P. Steward Daniel H. Palmer David Propper Balaji Venugopal Mirela Hategan Alan Anthoney Lisa V. Hampson Michael Nebozhyn David A. Tuveson Hayley Farmer-Hall Helen Turner Robert McLeod Sarah Halford Duncan I. Jodrell

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Abstract

Gemcitabine and a γ-secretase inhibitor (MK-0752) can be combined at their full, single-agent RP2Ds.

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Cook et al. (2018) studied this question.

synapsesocial.com/papers/69db1a3e4e9a02dbaa684f54 https://doi.org/10.1038/bjc.2017.495

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The Notch signaling pathway: Transcriptional regulation at Notch target genesReview · 2009 · 661 citations
2The Notch Signaling Pathway Is Related to Neurovascular Progression of Pancreatic CancerIn Vitro Study · 2005 · 103 citations
3Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.Human Clinical Trial · 1997 · 5,897 citations
4FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic CancerOriginal Research · 2011 · 7,800 citations
5Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinomaOriginal Research · 2012 · 97 citations

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