Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non–Small Cell Lung Cancer

Joshua K. Sabari; Vamsidhar Velcheti; K. Shimizu; Matthew R. Strickland; Rebecca S. Heist; Mohini Singh; Naema Nayyar; Anita Giobbie‐Hurder; Subba R. Digumarthy; Justin F. Gainor; Anant P. Rajan; Edwin Nieblas‐Bedolla; Aaron C. Burns; Jill Hallin; Peter Olson; James G. Christensen; Sylvia C. Kurz; Priscilla K. Brastianos; Hiroaki Wakimoto

doi:10.1158/1078-0432.ccr-22-0383

Abstract

These data support further development of adagrasib in patients with KRASG12C-mutant NSCLC with untreated BM. See related commentary by Kommalapati and Mansfield, p. 3179.

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Sabari et al. (2022) studied this question.

synapsesocial.com/papers/69db1d5937b5141e3ba3cd5b https://doi.org/10.1158/1078-0432.ccr-22-0383

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Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non–Small Cell Lung Cancer

Abstract

Discussion

Cite This Study

Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non–Small Cell Lung Cancer

Abstract

Discussion

Cite This Study

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