Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches
Population
Hepatitis C virus (HCV) RNA genome internal ribosome entry site (IRES) subdomain IIa
Comparison
Benzimidazole translation inhibitor vs Unbound RNA
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Offers a potential HCV IRES drug target; leaves open therapeutic validation in clinical models.
Structured PICO
P
Population
Hepatitis C virus (HCV) RNA genome internal ribosome entry site (IRES) subdomain IIa
I
Intervention
Benzimidazole translation inhibitor
C
Comparator
Unbound RNA
O
Outcome
Three-dimensional structure at 2.2 Å resolution and conformational adaptationsurrogate
The discovery of a ligand-induced binding pocket in the highly conserved HCV IRES subdomain IIa provides a structural basis for developing novel anti-HCV drugs.
Cite This Study
Dibrov et al. (2012) studied this question.