Why the study?
Do cardiopulmonary exercise testing parameters and clinical history predict morbidity and mortality in contemporary Fontan patients?
Do cardiopulmonary exercise testing parameters and clinical history predict morbidity and mortality in contemporary Fontan patients?
In contemporary Fontan patients, specific CPET parameters like decreased heart rate reserve and clinical factors identify those at high risk for poor outcomes, highlighting targets for medical or surgical attention.
May aid risk stratification in Fontan patients; leaves open whether CPET-guided interventions improve outcomes.
on short-term follow-up, most parameters of CPET are associated with increased risk of hospitalization but not death or transplantation in contemporary Fontan patients. Only decreased heart rate reserve and a history of clinically relevant arrhythmia, atriopulmonary/-ventricular Fontan, and/or heart failure requiring diuretic therapy are associated with poor prognosis, potentially identifying patients requiring medical and/or surgical attention.
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Diller et al. (2010) studied this question.
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