Why the study?
Does short-term hesperidin pretreatment protect against myocardial ischemia/reperfusion injury in rats?
Does short-term hesperidin pretreatment protect against myocardial ischemia/reperfusion injury in rats?
Hesperidin pretreatment demonstrates cardioprotective effects against ischemia/reperfusion injury in a rat model through modulation of the PI3K/Akt pathway and HMGB1.
Hesperidin may protect against rat myocardial I/R injury; hypothesis-generating and should not yet change clinical practice.
These findings suggest that short-term pretreatment with hesperidin protects against myocardial I/R injury by suppressing myocardial apoptosis, the inflammatory response and oxidative stress via PI3K/Akt pathway activation and HMGB1 inhibition.
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Li et al. (2016) studied this question.
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